Check out the chapter ‘The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans‘ from WormBook in GENETICS, by
WormShow: We regret to announce that Morris and Curtis have retired from doing the Worm Show. With the guidance of Ahna Skop we are planning a new format WormShow involving community submissions of videos or other performance art. More details will be available later on the meeting website but in the mean time please think about participating by producing a video!
–Marie-Anne Felix and Andrew Chisholm
Please take the Alliance of Genome Resources Survey. Your response is very important to us and will let funding agencies know how important model organism databases such as WormBase and other genome resources are to your research.
Model Organisms such as yeast, worm, fly, fish, and mouse are key drivers of biological research, providing experimental systems that yield insights into human biology and health. Model Organism Databases (MODs) and other genome resources like Gene Ontology (GO) Consortium enable researchers all over the world to uncover basic, conserved biological mechanisms relevant to new medical therapies.
NHGRI/NIH has recently advanced a plan to reduce MOD funding while encouraging these resources to share as much infrastructure as possible. While there are a number of advantages of more integration such as consistent user interfaces and vocabularies, unless other sources of funding are found to offset the planned cuts, core functions at WormBase such as extraction of information from papers and genome annotation will be affected. The Worm Board, worm community leaders and other model organism community leaders have come together to write a Statement of Support for the MODs and the GO. We ask all scientists who value the community-specific nature of the MODs to sign this ‘open letter’. We urge you to add your name, and to spread the word to all researchers who value these resources.
Please sign this letter!
The first chapter of WormBook in GENETICS, CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering, by Daniel J. Dickinson and Bob Goldstein, is now available!
The advent of genome editing techniques based on the clustered regularly interspersed short palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the biological sciences. CRISPR is quickly becoming an indispensible experimental tool for researchers using genetic model organisms, including the nematode Caenorhabditis elegans. Here, we provide an overview of CRISPR-based strategies for genome editing in C. elegans. We focus on practical considerations for successful genome editing, including a discussion of which strategies are best suited to producing different kinds of targeted genome modifications.