WS249: Parasite Papers II

For the upcoming WS249 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Rateb ME, Yang D, Vodanovic-Jankovic S, Yu Z, Kron MA, Shen B.Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. J Antibiot (Tokyo). 2015

Referenced Genes: Bma-nars-2

Yang Y, Wen Yj, Cai YN, Vallée I, Boireau P, Liu MY, Cheng SP.Serine proteases of parasitic helminths. Korean J Parasitol. 2015 Feb;53(1):1-11.

Referenced Genes: Bm10893, Bm4862, OVOC9258, OVOC9605

O’Connell EM, Bennuru S, Steel C, Dolan MA, Nutman TB.Targeting Filarial Abl-like Kinases: Orally Available, Food and Drug Administration-Approved Tyrosine Kinase Inhibitors Are Microfilaricidal and Macrofilaricidal. J Infect Dis. 2015 Feb 5.

Referenced Genes: OVOC2839, Bm3303, Bm3304

WS249: Parasite Papers I

For the upcoming WS249 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Winter AD, Weir W, Hunt M, Berriman M, Gilleard JS, Devaney E, Britton C.Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics. 2012 Jan 4;13:4.

miRNA genes are referenced from the WBPaper00040579 entry.

Winter AD, Gillan V, Maitland K, Emes RD, Roberts B, McCormack G, Weir W, Protasio AV, Holroyd N, Berriman M, Britton C, Devaney E. A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics. 2015 Apr 22;16(1):331.

referenced genes: let-7, Bm6643, Bm5914, Bma-tag-97, Bma-mir-5364

Cinkornpumin JK, Wisidagama DR, Rapoport V, Go JL, Dieterich C, Wang X, Sommer RJ, Hong RL. A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus. Elife. 2014 Oct 15;3

referenced genes: C06G1.1, Ppa-obi-1, CBG16343, CRE27642, CJA06526, Bm2019

Nuclear receptor chapter updated in WormBook

Nuclear receptor signal transduction in C. elegans, by Adam Antebi, has just been published in the Signal transduction section of WormBook. This chapter updates his 2006 chapter, Nuclear hormone receptors in C. elegans. The updated chapter discusses the role of nuclear receptors as regulators of life history, cell fate, and organogenesis, and their function in nutrient sensing, metabolism and energy homeostasis.

Please proceed to read this new chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane

WS248: Parasite Papers II

For the upcoming WS248 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Doharey PK, Suthar MK, Verma A, Kumar V, Yadav S, Balaramnavar VM, Rathaur S, Saxena AK, Siddiqi MI, Saxena JK. Molecular cloning and characterization of Brugia malayi thymidylate kinase. Acta Trop. 2014 May;133:83-92. doi:10.1016/j.actatropica.2014.02.003. Epub 2014 Feb 17.

genes referred to: Bm5401

Singh VK, Doharey PK, Kumar V, Saxena JK, Siddiqi MI, Rathaur S, Narender T.
Synthesis, molecular docking and Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition study of novel derivatives of [6]-shogaol. Eur J Med Chem. 2015 Mar 26;93:74-82. doi: 10.1016/j.ejmech.2015.01.035. Epub 2015 Jan 20.

genes referred to: Bm5401

Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA Jr, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C,
Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb 20;9(2):e0003534. doi: 10.1371/journal.pntd.0003534. eCollection 2015 Feb.

genes referred to: Bma-trxr-1