ParaSite Release 3

We are pleased to announce the third release of WormBase ParaSite, the home for parasitic worm draft genomes and genomic data in WormBase.

This release includes two new annotated genomes, taking the total number of nematode and flatworm genomes in WormBase ParaSite to 99, representing 90 species. The new genomes are:

  • Echinococcus canadensis (PRJEB8992)
  • Loa loa (PRJNA246086)

This release also includes a REST API, providing language-neutral programmatic access to ParaSite data via a RESTful interface (http://parasite.wormbase.org/api/), and an improved BLAST search which is faster and has no limit on the number of species that can be BLASTed against (http://parasite.wormbase.org/Tools/Blast).

Finally, in this release we are displaying tapeworm RNASeq data for the species Echinococcus granulosus, Echinococcus multilocularis and Hymenolepis microstoma (as example). We will be including more transcriptomic data sets in upcoming ParaSite releases so if you would like to suggest datasets you would like to see displayed please get in touch!

WS249: reorganization of parasitic non-core species

Starting with the WS249 release of WormBase we will point users to the new WormBase ParaSite portal for parasitic nematodes that are not curated as part of the WormBase core species.

Species that can now be found at WormBase ParaSite are:
Ancylostoma ceylanicum (PRJNA231479|PRJNA72583)
Ascaris suum (PRJNA62057|PRJNA80881)
Bursaphelenchus xylophilus (PRJEA64437)
Dirofilaria immitis (PRJEB1797)
Haemonchus contortus (PRJEB506|PRJNA205202)
Loa loa (PRJNA60051 )
Meloidogyne hapla (PRJNA29083)
Meloidogyne incognita (PRJEA28837)
Necator americanus (PRJNA72135)
Trichinella spiralis (PRJNA12603)
Trichuris suis (PRJNA179528|PRJNA208415|PRJNA208416)

WS249: Parasite Papers II

For the upcoming WS249 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Rateb ME, Yang D, Vodanovic-Jankovic S, Yu Z, Kron MA, Shen B.Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. J Antibiot (Tokyo). 2015

Referenced Genes: Bma-nars-2

Yang Y, Wen Yj, Cai YN, Vallée I, Boireau P, Liu MY, Cheng SP.Serine proteases of parasitic helminths. Korean J Parasitol. 2015 Feb;53(1):1-11.

Referenced Genes: Bm10893, Bm4862, OVOC9258, OVOC9605

O’Connell EM, Bennuru S, Steel C, Dolan MA, Nutman TB.Targeting Filarial Abl-like Kinases: Orally Available, Food and Drug Administration-Approved Tyrosine Kinase Inhibitors Are Microfilaricidal and Macrofilaricidal. J Infect Dis. 2015 Feb 5.

Referenced Genes: OVOC2839, Bm3303, Bm3304

WS249: Parasite Papers I

For the upcoming WS249 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Winter AD, Weir W, Hunt M, Berriman M, Gilleard JS, Devaney E, Britton C.Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics. 2012 Jan 4;13:4.

miRNA genes are referenced from the WBPaper00040579 entry.

Winter AD, Gillan V, Maitland K, Emes RD, Roberts B, McCormack G, Weir W, Protasio AV, Holroyd N, Berriman M, Britton C, Devaney E. A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics. 2015 Apr 22;16(1):331.

referenced genes: let-7, Bm6643, Bm5914, Bma-tag-97, Bma-mir-5364

Cinkornpumin JK, Wisidagama DR, Rapoport V, Go JL, Dieterich C, Wang X, Sommer RJ, Hong RL. A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus. Elife. 2014 Oct 15;3

referenced genes: C06G1.1, Ppa-obi-1, CBG16343, CRE27642, CJA06526, Bm2019

WormBase HUBs

As shown during the WormBase Workshops of the International Worm Meeting 2015 at UCLA:

(Slides/Notes of the WormBase ParaSite / HUBs section)

To enable use of up to date data on external sites, WormBase is providing with each release (starting with WS248), selected annotations and comparative tracks as assembly hubs.

there are currently two types of hubs,

the UCSC version:

and a version compatible with Ensembl Genomes (future WormBase ParaSite , Ensembl and BioDalliance releases)

(production HUBs are in synch with the current live WormBase release)