Check out the latest WormBook chapter in Genetics: The Natural Biotic Environment of Caenorhabditis elegans, by Hinrich Schulenburg and Marie-Anne Félix.
Check out the chapter ‘The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans‘ from WormBook in GENETICS, by
Check out the latest chapter of WormBook in Genetics, Cell Biology of the Caenorhabditis elegans Nucleus, by Orna Cohen-Fix and Peter Askjaer.
Check out the latest chapter in WormBook in GENETICS–‘Next-Generation Sequencing-Based Approaches for Mutation Mapping and Identification in Caenorhabditis elegans‘ by Maria Doitsidou, Sophie Jarriault and Richard J. Poole.
There’s a great new chapter of WormBook in GENETICS by Meera V. Sundaram and Matthew Buechner: The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and Plasticity.
The excretory system of the nematode Caenorhabditis elegans is a superb model of tubular organogenesis involving a minimum of cells. The system consists of just three unicellular tubes (canal, duct, and pore), a secretory gland, and two associated neurons. Just as in more complex organs, cells of the excretory system must first adopt specific identities and then coordinate diverse processes to form tubes of appropriate topology, shape, connectivity, and physiological function. The unicellular topology of excretory tubes, their varied and sometimes complex shapes, and the dynamic reprogramming of cell identity and remodeling of tube connectivity that occur during larval development are particularly fascinating features of this organ. The physiological roles of the excretory system in osmoregulation and other aspects of the animal’s life cycle are only beginning to be explored. The cellular mechanisms and molecular pathways used to build and shape excretory tubes appear similar to those used in both unicellular and multicellular tubes in more complex organs, such as the vertebrate vascular system and kidney, making this simple organ system a useful model for understanding disease processes.