Nuclear receptor chapter updated in WormBook

Nuclear receptor signal transduction in C. elegans, by Adam Antebi, has just been published in the Signal transduction section of WormBook. This chapter updates his 2006 chapter, Nuclear hormone receptors in C. elegans. The updated chapter discusses the role of nuclear receptors as regulators of life history, cell fate, and organogenesis, and their function in nutrient sensing, metabolism and energy homeostasis.

Please proceed to read this new chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane

WormBook: Operon chapter added

Dear WormBook reader,

Operon and non-operon gene clusters in the C. elegans genome, by Thomas Blumenthal, Paul Davis and Alfonso Garrido-Lecca, has been published in the Molecular biology section of WormBook. This chapter discusses a variety of tight-linkage gene arrangements in the C. elegans genome, summarizes the current knowledge on several variations of operon processing, and describes non-operon gene clusters.

Please proceed to read this new chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane

Ion transport chapter added to WormBook

Membrane ion transport in non-excitable tissues, by Keith Nehrke, has just been published in the Cell biology section. This chapter discusses calcium signaling during defecation, fertilization, locomotion, and wound closure, as well as the role of pH, proton signaling, and osmotic balance in C. elegans behavior and physiology.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook, and happy holidays!

Jane

WormBook: Polarity establishment chapter updated

Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos, by Lesilee Rose and Pierre Goenczy, has been published in the Developmental control and Cell biology sections of WormBook. This chapter updates their 2005 chapter, Asymmetric cell division and axis formation in the embryo. The updated chapter presents important progress in elucidating the mechanisms that transform an isotropic system into a polarized one in the first cell cycle, and further discusses how cell signaling in subsequent divisions builds upon the initial polarity to further refine cell fates.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Jane

Anthelmintic drug chapter updated in WormBook

Dear WormBook reader,

Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans, by Lindy Holden-Dye and Robert Walker, has been added to the Disease models and drug discovery section. This chapter updates the 2007 chapter, Anthelmintic drugs, also by Holden-Dye and Walker. This chapter discusses the use of C. elegans as a model ‘parasite’, and reviews its use in the study of nematode control and as a platform for anthelmintic and nematicide discovery and development.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane