Sydney Brenner, the Nobel prize-winning molecular biologist who pioneered the use of C. elegans as a model organism has passed away.
WormBase is up to date with curation of protein-protein interactions
We have now curated all C. elegans protein-protein interactions (physical) from the published literature. In the current release, WS269, we have over 30,000 binary gene pair interactions. Please let us know if we have missed anything!
New GENETICS WormBook Chapter on Developmental Control of the Cell Cycle
Check out the new chapter of WormBook in GENETICS–
‘Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans‘ by Edward T. Kipreos and Sander van den Heuvel.
Gene Ontology Consortium turns 20
The Gene Ontology (GO) resource turns 20! Check out the latest paper describing this resource. WormBase uses GO to describe the molecular function, cellular localization and the biological processes that a gene is involved in. These annotations are displayed in the Gene Ontology widget on all gene pages in WormBase. The ontology structure including the number of genes annotated to each term can be viewed via tools such as the Ontology Browser. GO Enrichment Analysis can be performed using tools on the GO website. Data files (known as gene association files) of all the GO annotations in the latest WormBase release (note that these are ahead of the live website) across the genome for C. elegans and several other nematode species can be found here on the WormBase FTP site.
Paper of Interest: Identification of functional long non-coding RNAs in C. elegans.
This paper predicts 143 new multi-exonic lncRNA loci in C. elegans, along with ~3,000 possible new single-exon lncRNA loci.