Focus on Parasite Papers

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For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Zang X, Atmadja AK, Gray P, Allen JE, Gray CA, Lawrence RA, Yazdanbakhsh M,
Maizels RM. The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong, but short-lived, immune responses in mice and humans. J Immunol. 2000 Nov 1;165(9):5161-9.

linked genes: Bma-srp-2
ParaSite: Bma-srp-2

Zang X, Yazdanbakhsh M, Jiang H, Kanost MR, Maizels RM. A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases. Blood. 1999 Aug 15;94(4):1418-28.

linked genes: Bma-srp-2
ParaSite: Bma-srp-2

Manoury B, Gregory WF, Maizels RM, Watts C. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr Biol. 2001 Mar 20;11(6):447-51.

linked genes: cpi-2 , Bm5160 , Bm10669
ParaSite: Bm5160 , Bm10669

C.elegans motion assay adapted for use in anthelminth studies

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A paper called Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: “The Worminator” was published by Bob Storey et al in the International Journal for Parasitology.

It describes a modification of the WormAssay software, a tool for motility studies in C.elegans.

These additions allow the analysis of the motility in microscopic lifestages, as found in parasitic nematodes, enabling new ways in automating anthelminth screens.

Anthelmintic drug chapter updated in WormBook

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Dear WormBook reader,

Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans, by Lindy Holden-Dye and Robert Walker, has been added to the Disease models and drug discovery section. This chapter updates the 2007 chapter, Anthelmintic drugs, also by Holden-Dye and Walker. This chapter discusses the use of C. elegans as a model ‘parasite’, and reviews its use in the study of nematode control and as a platform for anthelmintic and nematicide discovery and development.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane

Focus on Parasite Papers

by Leave a Comment

For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Yadav S, Gupta S, Selvaraj C, Doharey PK, Verma A, Singh SK, Saxena JK. In silico and in vitro studies on the protein-protein interactions between Brugia malayi immunomodulatory protein calreticulin and human C1q. PLoS One. 2014 Sep 3;9(9):e106413.

linked genes: Bm6412
ParaSite: Bma6412

Galvin BD, Li Z, Villemaine E, Poole CB, Chapman MS, Pollastri MP, Wyatt PG, Carlow CK. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3145.

linked genes: Bma-nmt-1 , nmt-1
ParaSite: Bma-nmt-1

Terry FE, Moise L, Martin RF, Torres M, Pilotte N, Williams SA, De Groot AS. Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases. Expert Rev Vaccines. 2014 Sep 5:1-15.

linked genes: Bma-prdx-2
ParaSite: Bma-prdx-2

WormBook: DNA repair chapter updated

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Dear WormBook reader,

Replication and repair by Ann Rose has just been added to the Molecular biology section of WormBook. This chapter updates and greatly expands the 2006 chapter DNA repair by Nigel O’Neil and Ann Rose. Over the past few years there has been an explosion of research using C. elegans to study many aspects of DNA repair and the updated chapter points to several recently published reviews. The new chapter summarizes those reviews and highlights the use of C. elegans in the study of the Fanconi Anemia (FA) repair pathway.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane