Ion transport chapter added to WormBook

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Membrane ion transport in non-excitable tissues, by Keith Nehrke, has just been published in the Cell biology section. This chapter discusses calcium signaling during defecation, fertilization, locomotion, and wound closure, as well as the role of pH, proton signaling, and osmotic balance in C. elegans behavior and physiology.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook, and happy holidays!

Jane

WormBook: Polarity establishment chapter updated

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Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos, by Lesilee Rose and Pierre Goenczy, has been published in the Developmental control and Cell biology sections of WormBook. This chapter updates their 2005 chapter, Asymmetric cell division and axis formation in the embryo. The updated chapter presents important progress in elucidating the mechanisms that transform an isotropic system into a polarized one in the first cell cycle, and further discusses how cell signaling in subsequent divisions builds upon the initial polarity to further refine cell fates.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Jane

Anthelmintic drug chapter updated in WormBook

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Dear WormBook reader,

Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans, by Lindy Holden-Dye and Robert Walker, has been added to the Disease models and drug discovery section. This chapter updates the 2007 chapter, Anthelmintic drugs, also by Holden-Dye and Walker. This chapter discusses the use of C. elegans as a model ‘parasite’, and reviews its use in the study of nematode control and as a platform for anthelmintic and nematicide discovery and development.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane

WormBook: DNA repair chapter updated

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Dear WormBook reader,

Replication and repair by Ann Rose has just been added to the Molecular biology section of WormBook. This chapter updates and greatly expands the 2006 chapter DNA repair by Nigel O’Neil and Ann Rose. Over the past few years there has been an explosion of research using C. elegans to study many aspects of DNA repair and the updated chapter points to several recently published reviews. The new chapter summarizes those reviews and highlights the use of C. elegans in the study of the Fanconi Anemia (FA) repair pathway.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane

WormBook chapter on Epithelial Junctions, cytoskeleton, and polarity updated

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Dear WormBook reader,

Epithelial junctions, cytoskeleton, and polarity, by Gabriella Pásti and Michel Labouesse, has just been added to the Cell biology section of WormBook. This chapter updates Epithelial junctions and attachments, by Michel Labouesse, originally published in 2006. Focusing on cellular aspects of epithelial cells, the chapter describes basic features of C. elegans apical junctions, establishment and maintenance of epithelial polarity, the epithelial cytoskeleton, and hemidesmosome-like cell-extracellular matrix junctions.

Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

Thank you for your interest in WormBook.

Jane