Human disease model data in WormBase

You don’t have to look anywhere else to see if the gene of your interest is a genetic model for human disease! Both manually curated and orthology-based human disease related data for genes is presented on the gene page in the the ‘Overview’ section and in the ‘Human Diseases’ widget in the side-bar. This data indicates whether the gene is an ‘Experimental model’ for a human disease based on experimental evidences from the manually curated literature, or a ‘Potential model’ based on orthology with a human gene/s. You can also search by a disease term (DO term) from the autocomplete search box at the top of every web page, eg., ‘Alzheimer’s disease’.  Currently, over 250 genes have been manually curated, for their relevance to human disease and several hundred genes are flagged as potential models, based on orthology to human disease genes. The relevant human genes from the Online Mendelian Inheritance in Man (OMIM) database and associated diseases are displayed as well. Currently we are working to improve disease displays and will continue to expand this data. Please let us know if we have missed a published experimental disease model in C. elegans!

Comments

  1. Jia says

    Hey, Rkishore, may I ask for the link of the site you mentioned above? how come I couldn’t find the page with “Overview” section.
    Thank you very much.
    Jia

    • rkishore says

      Hi Jia,
      On any given gene page, the ‘Overview section’ is right at the top. Note however, that a gene will have the ‘Disease relevance’ expand option, only if it has disease information. You might also want to have the ‘Human Diseases’ widget (in the side-bar) on, for a given gene, so you can see any orthology-based or manually curated disease information. Hope this helps!
      Ranjana

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