Check out the chapter ‘The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans‘ from WormBook in GENETICS, by
May 2016: 8 new labs joining the community
8 new labs have registered with WormBase and the CGC. Please join us in welcoming these labs to the community!
| Alex Mendenhall | ARM | wam | University of Washington, Seattle, WA | |
| Hiroaki Miki | CRB | dcr | Osaka University, Osaka, Japan | website |
| Megan Hwa Brewer | MHB | nna | Sydney Medical School, Concord, NSW, Australia | |
| Suhong Xu | SHX | zju | Zhejiang University, Hangzhou, Zhejiang, China | website |
| Tamara Mikeladze-Dvali | TMD | mik | Biozentrum der LMU Mnchen, Planegg-Martinsried, Germany | website |
| Matt Crook | TWP | mxc | Whitman College, Walla Walla, WA | |
| Anna K Allen | WDC | ana | Howard University, Washington, DC | website |
| Wolfgang Fischle | WFK | cbd | Max Planck Institute for Biophysical Chemistry, Goettingen, Germany | website |
Passing of Robert Stuart (Bob) Edgar, (1930 – 2016)
One of the pioneer spirits of our field, Bob Edgar, has died. Bob started the Worm Breeder’s Gazette in 1975 and helped organize early worm meetings. He played an essential role in fostering the collegiality that has distinguished the C. elegans field. Read about him here.
Focus on Parasite Papers
For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.
Zang X, Atmadja AK, Gray P, Allen JE, Gray CA, Lawrence RA, Yazdanbakhsh M,
Maizels RM. The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong, but short-lived, immune responses in mice and humans. J Immunol. 2000 Nov 1;165(9):5161-9.
linked genes: Bma-srp-2
ParaSite: Bma-srp-2
Zang X, Yazdanbakhsh M, Jiang H, Kanost MR, Maizels RM. A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases. Blood. 1999 Aug 15;94(4):1418-28.
linked genes: Bma-srp-2
ParaSite: Bma-srp-2
Manoury B, Gregory WF, Maizels RM, Watts C. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr Biol. 2001 Mar 20;11(6):447-51.
linked genes: cpi-2 , Bm5160 , Bm10669
ParaSite: Bm5160 , Bm10669
Focus on Parasite Papers
For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.
Yadav S, Gupta S, Selvaraj C, Doharey PK, Verma A, Singh SK, Saxena JK. In silico and in vitro studies on the protein-protein interactions between Brugia malayi immunomodulatory protein calreticulin and human C1q. PLoS One. 2014 Sep 3;9(9):e106413.
linked genes: Bm6412
ParaSite: Bma6412
Galvin BD, Li Z, Villemaine E, Poole CB, Chapman MS, Pollastri MP, Wyatt PG, Carlow CK. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3145.
linked genes: Bma-nmt-1 , nmt-1
ParaSite: Bma-nmt-1
Terry FE, Moise L, Martin RF, Torres M, Pilotte N, Williams SA, De Groot AS. Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases. Expert Rev Vaccines. 2014 Sep 5:1-15.
linked genes: Bma-prdx-2
ParaSite: Bma-prdx-2