New issue of The Worm Breeder's Gazette available

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Dear Worm Researchers,

Volume 20, Number 1 of The Worm Breeder’s Gazette has been published. In addition to a meeting announcement, several new lab announcements, worm art, and worm humor, this issue contains several articles describing new or improved techniques. These include improvements in the use of whole genome sequencing for mutant identification, a report on the use of CRISPR/Cas9 to target cis-regulatory regions, a multiply fluorescent strain for outcrossing Million Mutation Project alleles and linkage mapping, a method to improve growth in primary cultures of C. elegans cells, and an improved method for preserving histological samples.

Please proceed to read the exciting pieces of this new issue, and we look forward to your contribution to our next one.

Thank you for your interest in The Worm Breeder’s Gazette.

Sincerely,

Jane

Human disease model data in WormBase

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You don’t have to look anywhere else to see if the gene of your interest is a genetic model for human disease! Both manually curated and orthology-based human disease related data for genes is presented on the gene page in the the ‘Overview’ section and in the ‘Human Diseases’ widget in the side-bar. This data indicates whether the gene is an ‘Experimental model’ for a human disease based on experimental evidences from the manually curated literature, or a ‘Potential model’ based on orthology with a human gene/s. You can also search by a disease term (DO term) from the autocomplete search box at the top of every web page, eg., ‘Alzheimer’s disease’.  Currently, over 250 genes have been manually curated, for their relevance to human disease and several hundred genes are flagged as potential models, based on orthology to human disease genes. The relevant human genes from the Online Mendelian Inheritance in Man (OMIM) database and associated diseases are displayed as well. Currently we are working to improve disease displays and will continue to expand this data. Please let us know if we have missed a published experimental disease model in C. elegans!

Worm Breeder's Gazette submission deadline

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Dear Worm Researchers,

The deadline for submissions for the next issue of The Worm Breeder’s Gazette is Monday, March 10. The date is somewhat flexible, so if you need an extra day or two, please email me.

In addition to articles summarizing research results, we also welcome announcements, editorials, and artwork. We would also like to include articles describing the use of nematodes in teaching. In short, we will include anything that would be of interest to researchers or teachers of nematode biology.

Articles should be a single page in length and should be submitted through our web site: http://www.wormbook.org/wbg/. You should be able to register on the Gazette site, but it may take as much as a day before you receive email confirmation. If you have trouble registering, or don’t want to fool with it, please send your article to me and I will upload it for you.
Thank you for your interest in The Worm Breeder’s Gazette.

Sincerely,

Jane