WS247: Parasite Papers II

For the upcoming WS247 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Khor BY, Tye GJ, Lim TS, Noordin R, Choong YS. The structure and dynamics of BmR1 protein from Brugia malayi: in silico approaches. Int J Mol Sci. 2014 Jun 19;15(6):11082-99.

genes referred to: Bm10631 (other name: BmR1)

Anderson RC, Newton CL, Millar RP, Katz AA. The Brugia malayi neuropeptide receptor-4 is activated by FMRFamide-like peptides and signals via Gai. Mol Biochem Parasitol. 2014 Jun;195(1):54-8.

genes referred to: flp-18 , npr-4 , Bma-npr-4

Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT. The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a. Proteins. 2014 Dec;82(12):3490-6.

genes referred to: daf-16 , Bma-daf-16

Kalani K, Kushwaha V, Sharma P, Verma R, Srivastava M, Khan F, Murthy PK, Srivastava SK. In vitro, in silico and in vivo studies of ursolic acid as an anti-filarial agent. PLoS One. 2014 Nov 6;9(11):e111244.

genes referred to: Bma-gst-1

Yadav M, Singh A, Rathaur S, Liebau E. Structural modeling and simulation studies of Brugia malayi glutathione-S-transferase with compounds exhibiting antifilarial activity: implications in drug targeting and designing. J Mol Graph Model. 2010 Jan;28(5):435-45.

genes referred to: Bma-gst-1

WS247: Parasite Papers I

For the upcoming WS247 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Rodrigo WW, Dassanayake RS, Weerasena SJ, Silva Gunawardene YI. Novel parasitic nematode-specific protein of bovine filarial parasite Setaria digitata displays conserved gene structure and ubiquitous expression. Trop Biomed. 2014 Sep;31(3):514-24.

genes referred to: Bm8739

Tiwari S, Wadhawan M, Singh N, Rathaur S. Effect of CDNB on filarial thioredoxin reductase : A proteomic and biochemical approach. J Proteomics. 2015 Jan 15;113:435-46.

genes referred to: ced-3 , ced-9 , Bma-trxr-1 , Bma-ced-3 , Bm14668

Kulke D, von Samson-Himmelstjerna G, Miltsch SM, Wolstenholme AJ, Jex AR, Gasser RB, Ballesteros C, Geary TG, Keiser J, Townson S, Harder A, Kruecken J Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3401.

genes referred to: sle-1 , slo-1 , Bma-slo-1 , Ovo-slo-1

Lustigman S, Melnikow E, Anand SB, Contreras A, Nandi V, Liu J, Bell A, Unnasch TR, Rogers MB, Ghedin E. Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia. Int J Parasitol Drugs Drug Resist. 2014 Aug 26;4(3):267-77.

genes referred to: Bm1665 , Bma-cpl-6 , Bma-cpl-2 , Bma-cpl-7 , Bma-cpl-8 , Bma-cpl-4 , Bma-cpl-5 , Bma-cpl-1

Focus on Parasite Papers

For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Zang X, Atmadja AK, Gray P, Allen JE, Gray CA, Lawrence RA, Yazdanbakhsh M,
Maizels RM. The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong, but short-lived, immune responses in mice and humans. J Immunol. 2000 Nov 1;165(9):5161-9.

linked genes: Bma-srp-2
ParaSite: Bma-srp-2

Zang X, Yazdanbakhsh M, Jiang H, Kanost MR, Maizels RM. A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases. Blood. 1999 Aug 15;94(4):1418-28.

linked genes: Bma-srp-2
ParaSite: Bma-srp-2

Manoury B, Gregory WF, Maizels RM, Watts C. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr Biol. 2001 Mar 20;11(6):447-51.

linked genes: cpi-2 , Bm5160 , Bm10669
ParaSite: Bm5160 , Bm10669

Focus on Parasite Papers

For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Yadav S, Gupta S, Selvaraj C, Doharey PK, Verma A, Singh SK, Saxena JK. In silico and in vitro studies on the protein-protein interactions between Brugia malayi immunomodulatory protein calreticulin and human C1q. PLoS One. 2014 Sep 3;9(9):e106413.

linked genes: Bm6412
ParaSite: Bma6412

Galvin BD, Li Z, Villemaine E, Poole CB, Chapman MS, Pollastri MP, Wyatt PG, Carlow CK. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3145.

linked genes: Bma-nmt-1 , nmt-1
ParaSite: Bma-nmt-1

Terry FE, Moise L, Martin RF, Torres M, Pilotte N, Williams SA, De Groot AS. Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases. Expert Rev Vaccines. 2014 Sep 5:1-15.

linked genes: Bma-prdx-2
ParaSite: Bma-prdx-2

Focus on Parasite Papers

For the upcoming WS246 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Coles GC, Bauer C, Borgsteede FH, Geerts S, Klei TR, Taylor MA, Waller PJ. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol. 1992 Sep;44(1-2):35-44.

linked genes: Bma-pdi-2
ParaSite: Bma-pdi-2

Wiśniewski M, Lapiński M, Zdziarska A, Długosz E, Bąska P. Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase. Mol Biochem Parasitol. 2014 Aug;196(1):12-20.

linked genes: Bma-gcs-1 Acey_s0084.g1747
ParaSite: (there are two alternative assemblies on ParaSite for A.ceylanicum) Acey_s0084.g1747 ANCCEY_09480 Bma-gcs-1

Jawaharlal JP, Madhumathi J, Prince RP, Kaliraj P. Repeat region of Brugia malayi sheath protein (Shp-1) carries Dominant B epitopes recognized in filarial endemic population. Acta Parasitol. 2014 Sep;59(3):454-8.

linked genes: Bma-shp-1
ParaSite: Bma-shp-1