Due to non-stringent human ortholog(s) and their associated diseases, C. elegans gene descriptions (displayed in the “Overview widget” of gene pages) often had spurious diseases associated with their human orthologs. With WS279, we imposed a stringency filter and only those disease associations to ortholog(s) called by more than one orthology prediction method are included in the gene description. This change has improved the accuracy of statements that read “human orthologs of this gene are implicated in <disease(s)>”. However, please note that this change has also resulted in the loss of such statements for several hundred gene descriptions due to the increased stringency.
WormBase has been updated to the WS279 release of the database. In this release, we’ve refined the feedback mechanism and improved error handling behind the scenes. You can read more about the curation statistics of the WS279 release in the release notes.