WS247: Parasite Papers II

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For the upcoming WS247 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Khor BY, Tye GJ, Lim TS, Noordin R, Choong YS. The structure and dynamics of BmR1 protein from Brugia malayi: in silico approaches. Int J Mol Sci. 2014 Jun 19;15(6):11082-99.

genes referred to: Bm10631 (other name: BmR1)

Anderson RC, Newton CL, Millar RP, Katz AA. The Brugia malayi neuropeptide receptor-4 is activated by FMRFamide-like peptides and signals via Gai. Mol Biochem Parasitol. 2014 Jun;195(1):54-8.

genes referred to: flp-18 , npr-4 , Bma-npr-4

Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT. The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a. Proteins. 2014 Dec;82(12):3490-6.

genes referred to: daf-16 , Bma-daf-16

Kalani K, Kushwaha V, Sharma P, Verma R, Srivastava M, Khan F, Murthy PK, Srivastava SK. In vitro, in silico and in vivo studies of ursolic acid as an anti-filarial agent. PLoS One. 2014 Nov 6;9(11):e111244.

genes referred to: Bma-gst-1

Yadav M, Singh A, Rathaur S, Liebau E. Structural modeling and simulation studies of Brugia malayi glutathione-S-transferase with compounds exhibiting antifilarial activity: implications in drug targeting and designing. J Mol Graph Model. 2010 Jan;28(5):435-45.

genes referred to: Bma-gst-1

WS247: Parasite Papers I

by Leave a Comment

For the upcoming WS247 release, a set of new papers have been added to the WormBase database. Some papers of interest to the parasite community are shown below.

Rodrigo WW, Dassanayake RS, Weerasena SJ, Silva Gunawardene YI. Novel parasitic nematode-specific protein of bovine filarial parasite Setaria digitata displays conserved gene structure and ubiquitous expression. Trop Biomed. 2014 Sep;31(3):514-24.

genes referred to: Bm8739

Tiwari S, Wadhawan M, Singh N, Rathaur S. Effect of CDNB on filarial thioredoxin reductase : A proteomic and biochemical approach. J Proteomics. 2015 Jan 15;113:435-46.

genes referred to: ced-3 , ced-9 , Bma-trxr-1 , Bma-ced-3 , Bm14668

Kulke D, von Samson-Himmelstjerna G, Miltsch SM, Wolstenholme AJ, Jex AR, Gasser RB, Ballesteros C, Geary TG, Keiser J, Townson S, Harder A, Kruecken J Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3401.

genes referred to: sle-1 , slo-1 , Bma-slo-1 , Ovo-slo-1

Lustigman S, Melnikow E, Anand SB, Contreras A, Nandi V, Liu J, Bell A, Unnasch TR, Rogers MB, Ghedin E. Potential involvement of Brugia malayi cysteine proteases in the maintenance of the endosymbiotic relationship with Wolbachia. Int J Parasitol Drugs Drug Resist. 2014 Aug 26;4(3):267-77.

genes referred to: Bm1665 , Bma-cpl-6 , Bma-cpl-2 , Bma-cpl-7 , Bma-cpl-8 , Bma-cpl-4 , Bma-cpl-5 , Bma-cpl-1

WormBase ParaSite release 2: more genomes and new data-mining tool

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We are pleased to announce the second release of WormBase ParaSite, the home for parasitic worm draft genomes and genomic data in WormBase.

This release includes eight new annotated genomes, taking the total number of nematode and flatworm genomes in WormBase ParaSite to 97, representing 89 species. The new genomes include:

* Fasciola hepatica (PRJEB6687)
* Opisthorchis viverrini (PRJNA222628)
* Pristionchus exspectatus (PRJEB6009)
* Five Steinernema genomes, including Steinernema carpocapsae (PRJNA202318)

    This release also includes a new data-mining tool, the WormBase ParaSite BioMart. The interface and underlying software for this are based on the Ensembl BioMart, the main difference being that WormBase ParaSite BioMart collects data for all species into a single underlying database. This means that a single query can be used to filter and report data from multiple species at once, for example all species of a given taxonomic clade.

    Ion transport chapter added to WormBook

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    Membrane ion transport in non-excitable tissues, by Keith Nehrke, has just been published in the Cell biology section. This chapter discusses calcium signaling during defecation, fertilization, locomotion, and wound closure, as well as the role of pH, proton signaling, and osmotic balance in C. elegans behavior and physiology.

    Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

    Thank you for your interest in WormBook, and happy holidays!

    Jane

    WormBook: Polarity establishment chapter updated

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    Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos, by Lesilee Rose and Pierre Goenczy, has been published in the Developmental control and Cell biology sections of WormBook. This chapter updates their 2005 chapter, Asymmetric cell division and axis formation in the embryo. The updated chapter presents important progress in elucidating the mechanisms that transform an isotropic system into a polarized one in the first cell cycle, and further discusses how cell signaling in subsequent divisions builds upon the initial polarity to further refine cell fates.

    Please proceed to read this chapter and others on nematode biology at http://www.wormbook.org/. If you have any comments or suggestions, please submit them via the Feedback page on wormbook.org.

    Jane