Kindly, Dr. Itai Antoine Toker made us aware of the paper Uyar et al. Genome Research 2012 (PMID: 22772596/ WBPaper00041271), which contains a genome-wide set of operon predictions for C. briggsae. The data was mapped forward to the current gene set using the Sequence IDs supplied. 1034 operons were captured from the publication, but because of the time between publication and extensive re-annotation of C. briggsae only 709 of these operons had enough information to allow us to map them precisely onto the genome and supplement the C. briggsae operon JBrowse track. If you find some interesting dataset you’d like WormBase to curate, please let us know at [email protected]
3D structures for all proteins
AlphaFold is an AI system, created in partnership between DeepMind and the EMBL-European Bioinformatics Institute (EMBL-EBI), that makes predictions of a protein’s structure from its amino-acid sequence. Go to their webpage to look at your favourite protein from C. elegans, Brugia, Onchocerca, Strongyloides, Trichuris or Wuchereria. If your favourite protein is missing, remember that any protein with >90% amino acid similarity is quite likely to have a very similar structure. And if you spot any structure that does not look right contact [email protected], and we’ll forward your feedback.
New Chapter in WormBook, GENETICS – Natural Genetic Variation as a Tool
Check out this new chapter in WormBook, GENETICS, “Natural genetic variation as a tool for discovery in Caenorhabditis nematodes” by Erik C. Andersen and Matthew V. Rockman (published Jan 04, 2022).
Update on CeNeuro2022
Dear Participants of CeNeuro 2022,
We look forward to a rich and stimulating meeting this summer! To remind everyone, the date is set for July 24-27, 2022.
As uncertainty around the world continues, we cannot make a decision on the format at the moment. We desperately hope to be able to organize a hybrid meeting and welcome as many people as possible in person, in Vienna. However, we will re-evaluate this decision in mid/end of March and and if a hybrid meeting is not possible, we will still hold an online only meeting.
Regardless of the final format, please note that the deadline for abstract submission will be at the end of April. Thank you for your patience and understanding of the challenges associated with organizing such events at the moment.
We wish you a wonderful 2022,
–The CeNeuro2022 organizers – Henrik Bringmann, Luisa Cochella, Alexander Gottschalk, Manuel Zimmer.
Two new genes in C. elegans!
After more than 20 years of careful manual curation of C. elegans, it is quite unusual to find new protein-coding genes. But in release WS283 we have no less than 2 new genes! We were alerted to the first one by Dr. Adam Norris from Southern Methodist University, Dallas, TX, USA. Working with WormBase curators, we were able to comprehensively annotate the new gene. As finding a new gene is such a remarkable event, Dr. Norris opted for writing a micropublication describing the new gene WBGene00306123 (Y97E10C.2). Iyengar, A; Diamantakis, S; Norris, A (2021), “A new gene on C. elegans chromosome V”
Buoyed by the first discovery, WormBase curators looked through our curation records and found a second new gene to annotate: WBGene00306124 (W04B5.9). Both of these new genes are in release WS283, and we look forward to learning even more about the biology of these new genes.
If you happen to spot what you think is a new gene – please email [email protected] to let our curators know about it!