WormBase updated to WS276

by Leave a Comment

A new release of WormBase, WS276 is live on the website. Please see the release notes which contain complete information about this release.

Data changes: note that C. elegans gene descriptions in the “Overview” section of gene pages have improved orthology statements to human genes. WormBase uses the DIOPT orthology data from the Alliance of Genome Resources and has increased stringency by displaying only those human orthologs that have been determined by three or more methods. This should significantly improve the orthology data in WormBase which is also reflected in the gene descriptions. 

Known Issues: the circRNAs failed mapping so sequence and genomic position are not available for this release, but will be in the WS277 release.

Coming orthology data changes in WormBase WS276

by Leave a Comment

Many of you have written to us in the past and pointed out some spurious human orthology calls for elegans genes, most of these have been noticed in the gene descriptions that appear in the Overview widget on the gene page. WormBase now uses the DIOPT orthology data from the Alliance of Genome Resources and has increased stringency by displaying only those human orthologs that have been determined by three or more methods. This should significantly improve the orthology data in WormBase which is reflected in the gene descriptions. Note that this change will go live in the WS276 version of WormBase coming soon (late April, 2020).